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Official websites use. Share sensitive information only on official, secure websites. Andreas H. Email: ahjacobs uni-muenster. The value of combined L- methyl -[ 11 C] methionine positron-emitting tomography MET-PET and magnetic resonance imaging MRI with regard to tumor extent, entity prediction, and therapy effects in clinical routine in patients with suspicion of a brain tumor was investigated.
Tumor sizes as defined by thresholding based on tumor-to-background ratios were significantly different as determined by MET-PET The diagnostic gold standard is open biopsy with limitations due to tumor heterogeneity. Magnetic resonance imaging MRI is the method of choice at primary diagnosis and detects tumor tissue with high sensitivity at high resolution. In the past, PET data in patients with brain tumors have been acquired and published in well-defined patient populations.
Therefore, assessing the usefulness of combined PET and MRI in a larger patient cohort, as it occurs in the clinical routine, is warranted. It should be pointed out that in contrast to previous reports, we ensured that for all imaging results a tumor sample is present for comparative histology.
For this type of study, the requirement to obtain informed consent was waived. The 70 examinations were performed in 12 children and 53 adults with a median age of 48 years range, years. The individual patient data and indication for imaging are depicted in Supplements I; Supplementary Tables 1 and 2; Supplementary Figure 1.
Parallel box plots of tumor volume TV as measured by visualization and analysis framework volume rendering engine Voreen. The MET was synthesized according to the method of Schmitz et al. Magnetic resonance imaging of the brain was acquired using two 1. Only tissue with signals above this threshold was defined as possible tumor tissue.