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October 5, at am. Two Australian scientists who showed that bacteria can cause stomach ulcers have won the Nobel Prize for Physiology or Medicine. The researchers made their discovery 23 years ago, at a time when ulcers were thought to result mainly from excess stomach acid brought on by stress and spicy food. In , J. Robin Warren, a pathologist at the Royal Perth Hospital, noticed a curved bacterium in stomach-tissue samples from a patient. A few years later, a gastroenterologist at the hospital, Barry J.
Marshall, cultured the microbeβultimately named Helicobacter pylori. The two scientists then found H. Today, gastroenterologists estimate that H. Antibiotics plus acid-blocking drugs routinely cure the disease.
Over the past decade, treatment has made H. However, Blaser recalls a scientific meeting in Brussels at which Marshall presented his early findings. The following year, a frustrated Marshall took an extreme step: He swilled a vial of live H. Within a week, he developed raging gastritis. Treatment with an antibiotic and bismuth, which had shown some efficacy against ulcers, eradicated the microbe.
Finally, large-scale trials in the early s established that antibiotics coupled with acid-blocking drugs or bismuth indeed knock out the microbe and cure ulcers. The discovery of H. Peek Jr. With their work, Peek says, Warren and Marshall showed that H. Other researchers have since linked inflammation of various origins to malignancies.
In some cases, H. Molecule could be key to stomach ailment. Three physicists who advanced the understanding and measurement of light have won the Nobel Prize in Physics.