Official websites use. Share sensitive information only on official, secure websites. A sub-analysis of a prospective, multicenter non-representative cohort study conducted in ICUs in 24 countries. Median time to its diagnosis was 20 days IQR Median time to positivity of blood culture was longer in fungemia than in bacteremia Candida albicans was the most frequent fungus isolated No clear source of HAF was detected in Compared to patients with bacteremia, HAF patients had a higher rate of septic shock Adequate treatment started within 24 h after blood culture collection was less frequent in HAF patients The day all cause fatality was According to multivariate analysis, only liver failure OR Patients with HAF present more frequently with septic shock and renal dysfunction on ICU admission and have a higher rate of renal failure at diagnosis.
Liver failure, need for mechanical ventilation and ICU admission for medical reason were the only independent predictors of day mortality. The online version of this article doi Bloodstream infection s BSI in the critically ill patients are a major cause of morbidity and mortality. The prognosis of BSI also varies, depending on several factors related to the host, the pathogen and the antimicrobial agent.
The incidence of invasive fungal infections has increased steadily, namely due to the increasing number of both immunocompromised and critically ill patients. In the last decades, we faced a worldwide rise in the prevalence of candidemia, particularly in the ICU [ 2 β 6 ].
Outstandingly, after controlling for confounders, candidemia has been identified as an independent predictor of mortality [ 16 ]. In addition, it prolongs hospital length of stay and increases costs associated with patient management [ 13 , 17 ].
Therefore, it is important to identify potentially modifiable prognostic factors to improve this poor outcome. Few independent prognostic factors have been identified in critically ill patients with candidemia. Adequate initial therapy is of paramount importance for a successful outcome. In general, early administration of antimicrobial agents is associated with a better outcome [ 18 ].
