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Fungal rhinosinusitis FRS has a worldwide distribution, comprises distinct clinical entities but is mostly due to Aspergillus among which Aspergillus fumigatus plays a major role in European countries. Although, there is accumulating evidence for the emergence of environmentally acquired-azole resistance in A. In this study, we aimed to investigate the prevalence of A.
One hundred and thirty-seven patients with FRS admitted between and at four French medical centres were retrospectively enrolled. Clinical and mycological findings were collected. Despite the presence of fungal hyphae at direct microscopic examination, mycological cultures remained negative for 83 out of the patients The PCR assay proved to be useful allowing the identification of A.
Importantly, neither TR 34 nor L98H alterations were evidenced. Abstract Fungal rhinosinusitis FRS has a worldwide distribution, comprises distinct clinical entities but is mostly due to Aspergillus among which Aspergillus fumigatus plays a major role in European countries. Publication types Multicenter Study.
Substances Antifungal Agents Azoles.