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In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. However, with extensive and in-depth investigations, researchers have discovered that its role can be expanded to a variety of signaling mechanisms, biological processes, human diseases, and treatment options. The p52 subunit then binds to RelB and undergoes nuclear translocation, promoting lymphocyte generation, survival, maturation, and adhesion.
Hailing Hsu et al. The C-terminus of A20 acts as a ubiquitin ligase for Klinked polyubiquitination, leading to the proteasomal degradation of RIP. T cells and B cells are the main cell types responsible for adaptive immune. Signaling molecules transmit regulatory signals intracellularly or extracellularly and act as receptors, ligands, protein kinases, or transcription factors in signaling pathways.
The different signaling pathways constitute a signal transduction network with a fine-grained regulatory system through mutual interactions.
MAPK signaling is a conserved enzymatic cascade that mediate signal transduction from the cell surface to the nucleus through phosphorylation events. MAPK is responsible for phosphorylating target proteins in the cytoplasm or nucleus. JNK activates c-Jun and activator protein-1 AP-1 to exert pro-oncogenic effects, while simultaneously inducing apoptosis.
