Official websites use. Share sensitive information only on official, secure websites. This study aimed to compare the effectiveness of lidocaine with magnesium sulphate in patients undergoing root canal treatment following irreversible pulpitis. A total of 86 patients were randomised to receive 1. Preoperative visual analogue scale VAS pain scores were recorded. Patients were instructed to report any perioperative pain felt during the access cavity preparation and when introducing the first patency file 10 k in the root canal and perioperative VAS recorded.
The MGS group produced better anaesthetic efficacy with a p-value of 0. Keywords: Anaesthetic effectiveness, irreversible pulpitis lidocaine, magnesium sulphate. Magnesium, a physiological and pharmacological blocker of NMDA, has antinociceptive effects in irreversible pulpitis.
The main goal of endodontic therapy is forestallment and treatment of conditions of the dental pulp with irreversible pulpitis 1. The failure of local anaesthesia or difficulty in obtaining satisfactory analgesia in patients with irreversible pulpitis causes excruciating pain during the root canal treatment, which instils fear and may restrain patients from receiving treatment 2.
It also causes metabolic acidosis, lowering the pH of affected tissues and activating the peripheral free terminals of nociceptive neurons 3. The posterior mandibular teeth are anaesthetised by the IANB, which is the conventional and superior technique 4.
To overcome this anaesthetic failure, modifications and the addition of adjuncts to the anaesthetic formulations have been made. Neurophysiological studies have demonstrated that magnesium is a physiological and pharmacological blocker of N-methyl-D-aspartate NMDA receptors in neuronal tissue and can block voltage-dependent ion channels, thus providing an antinociceptive effect 7.
