The aim of this study was to examine the relationship between the IL concentration with histopathological and clinical characteristics of PC patients. IL concentration was determined in serum, urine and prostate massage secret pms samples of 88 CP patients initially and after therapy , 20 benign prostatic hyperplasia BPH patients and 15 healthy controls. PC patients without any histopathological sign of tumor invasion had a significantly increased serum IL, either before or after the therapy, compared to the patient group with evident invasion of tumor cells.
The therapy induced different IL profile in serum and urine samples. PC patients without any histopathological signs of tumor invasion before the therapy have significantly increased serum IL concentration compared to those with the signs of tumor invasion. There is a clear dissociation of IL values between a serum sample and local, urine and pms samples from a particular patient.
After the therapy, high IL serum concentration is present only in patients with high Gleason score, present infiltration of peritumoral tissue and high tumor volume. Serum cytokine profiles in patients with prostate car-cinoma. Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer.
J Clin Invest ; 5 : — Paradoxical roles of the immune system during cancer development. Australian Prostate Cancer BioResource. Compre-hensive analysis of the cytokine-rich chromosome 5q Proin-flammatory cytokines in prostate cancer development and progression promoted by high-fat diet. Biomed Res Int ; Longitudinal cytokine expression during IMRT for prostate cancer and acute treatment toxicity.
Cytokine profiling of docetaxel-resistant castra-tion-resistant prostate cancer. Immunomodula-tory IL binding protein is produced by prostate cancer cells and its levels in urine and serum correlate with tumor status.
